Causes of Pancreatic cancer

In this article, we will discuss about causes of pancreatic cancer . It is a gland that lies between the stomach and spine that produces hormones required to control blood sugar and enzymes that aid in digestion such as insulin. The growth of cancerous and noncancerous cells in the pancreas can result in different types of cancers or tumors. Of which the most common usually begins in the cells that line ducts that carry digestive enzymes. However, if detected at early stages cancer can be mostly curable. There is a several factor that causes pancreatic cancer: Age: The major risk factor of pancreatic cancer is age and the risk increases with age. The ages between 60 to 80 years of age are at greater risk of developing this cancer. Additionally, it is uncommon in the age group under 40 yet there is some case where the young age group can also suffer pancreatic cancer. The reason behind this could be a certain risk factor of radiation therapy during childhood. Genetics: Genes play an important role in tumor formation. The genetic mutation increases the risk of pancreatic cancer. The risk increases with several inherited cancer syndromes. Furthermore, a family history of pancreatic cancer increases the risk of developing one. Smoking: smoking increases the risk of pancreatic cancer. The risk is higher in those who smoke more cigarettes during their lifetime. As smoking is associated with risks, if one lowers the intake of cigarette smoking the risk of pancreatic cancer drops close to normal making this factor a preventable cause or factor of pancreatic cancer risk. Obesity: Women are at higher risk of pancreatic cancer due to obesity. You might be more likely to get pancreatic cancer if you are obese. Being obese significantly increases the risk of cancer. Diabetes: Long-term condition of diabetes also increases the risk of cancer.  People with diabetes have increased risk, moreover, the sudden onset of diabetes is one of the symptoms of pancreatic cancer especially Type 2 diabetes. Chronic pancreatitis: A permanent inflammation of the pancreas is known as pancreatic cancer. It has been associated with an increased risk of pancreatic cancer. This is thought to be due to the repeated cycles of damage and healing that occur during chronic pancreatitis, as well as the release of substances that cause inflammation. It’s important to note that not only is pancreatitis a risk factor for pancreatic cancer, but pancreatic cancer can also cause pancreatitis if it blocks the pancreatic duct. The risk of pancreatic cancer is significantly increased when smoking, long-standing diabetes, and a poor diet are combined, compared to any of these factors alone. As pancreatic cancer advances, it can lead to complications such as the spread of cancer cells to nearby blood vessels, lymph nodes, and eventually to other parts of the body such as the liver, lining of the abdominal cavity, and lungs. The majority of cases of pancreatic cancer are diagnosed when cancer has already spread beyond the pancreas. MS (NMC Regd.2902) Dr.Kapendra Shekhar Amatya Head of the Department, Sr.Consultant Surgical Oncologist at Nepal Cancer Hospital and Research Center Director: Breast Cancer Program Interest: Breast Cancer Surgery, Gastro Intestinal Cancer Surgery (Stomach and Colo-Rectal Cancer) Consult now

Pancreatic Cancer?

Pancreatic Cancer

An abnormal growth or division of cells in the pancreas leads to pancreatic cancer. Located near the spine, the pancreas produces digestive enzymes deep in the abdomen. By producing enzymes and hormones, it aids digestion and controls blood sugar levels. The pancreas is composed of cells. A cell divides when it is needed to create a new one. As cells age, they die and are replaced by new ones. This process can fail sometimes. Whenever the body does not need new cells, or old cells are not destroyed, new cells are formed. As a result of the extra cells, a tumor may develop. Tumors can be benign. Their abnormality does not allow them to invade other parts of the body. It is called cancer when the tumor is malignant. This can lead to the cells growing out of control and spreading to other organs and tissues. Cancer that starts in the pancreas can still be called pancreatic cancer even after it has spread to another part of the body. There are several organs where pancreatic cancer can spread, including the liver, abdomen wall, lungs, bones, and lymph nodes. Causes of Pancreatic Cancer: Cancer is caused by changes in the DNA of your body. Parents can pass on these traits to their children or they can develop over time. You can develop changes over time if you’ve been exposed to something harmful. It is also possible for them to occur at random. It is unclear what causes pancreatic cancer. The majority of pancreatic cancers are hereditary or familial. Smoking, obesity, and aging are the main causes of pancreatic cancer. You may be more likely to develop pancreatic cancer if you have a first-degree relative with the disease. When a family member has pancreatic cancer, genetic testing is strongly recommended. Genetic testing is often not necessary if your results are negative. Types of Pancreatic Cancer: Pancreatic cancer comes in many forms, but exocrine cancer is the most common. You are likely to have exocrine pancreatic cancer if you have been diagnosed with pancreatic cancer. Pancreatic adenocarcinoma:  In about 95% of cases, exocrine pancreatic cancer is an adenocarcinoma. Pancreatic cancer usually starts in the ducts of the pancreas. They are called acinar cell carcinomas when they arise from the cells that produce pancreatic enzymes. Less common exocrine cancer: These cancers are less common than those caused by exocrine hormones, including adenosquamous carcinomas, squamous cell carcinomas, signet ring cell carcinomas, and undifferentiated carcinomas. Ampullary cancer: A bile duct, pancreatic duct, and small intestine duct form the ampulla of Vater, which is where this cancer begins. The treatment for ampullary cancer is similar to that for pancreatic cancer, although they aren’t technically pancreatic cancers. Ampullary cancer often blocks the bile duct when it is still small and has not spread much. Major Symptoms of Pancreatic Cancer: Some pancreatic cancers don’t have symptoms, or they are hard to detect. It can cause the following symptoms: Your skin may also become itchy, your pee may be darker, and your poo may be paler than usual Unintentional weight loss or loss of appetite Having no energy or feeling tired Having a high temperature or feeling hot and shivering. You may also experience digestive problems if you have any of the following symptoms: Sickness or feeling unwell Constipation or diarrhea, or other changes in your bowel movements You may experience pain in your tummy and back when you’re eating or lying down, but it may go away when you lean forward Indigestion symptoms, such as feeling bloated. Consumption of tobacco: The risk of pancreatic cancer is greatly increased by smoking. As compared to people who don’t smoke, people who smoke have about twice the risk of developing this cancer. It is believed that approximately 25% of pancreatic cancer cases are caused by cigarette smoking. The risks are also increased by smoking cigarettes and using smokeless tobacco products. As soon as a person stops smoking, their risk of pancreatic cancer decreases. Risk Factors to Look After for Pancreatic Cancer: Any factor that increases your chances of contracting a disease, such as cancer, is a risk factor. There are different risk factors for different types of cancer. There is no guarantee that you will get cancer just because you have a risk factor. People may not be aware of the factors that contribute to cancer risk. The following factors increase the risk of pancreatic cancer. Obesity:  Pancreatic cancer is associated with being very overweight. The risk of pancreatic cancer is about 20% higher for obese individuals. The risk of developing diabetes can also be increased by gaining weight as an adult. People who are not very overweight may also be at risk of carrying excess weight around the waistline. Diabetes: People with diabetes are more likely to develop pancreatic cancer. There is no explanation for this. Type 2 diabetics are at the greatest risk. In children and adolescents, these types of diabetes are on the rise as obesity also increases in these groups. Being overweight and obese are also associated with type 2 diabetes in adults. Type 1 diabetes is not known to be riskier. Chronic pancreatitis: It is known that chronic pancreatitis, an inflammation of the pancreas over a long period, increases the risk of pancreatic cancer. As a result of heavy alcohol consumption and smoking, chronic pancreatitis often develops. Chemical exposure in the workplace: People who work in the dry cleaning and metal working industries may be more likely to develop pancreatic cancer if they are exposed to certain chemicals at work. Diagnosis of Pancreatic Cancer: To determine the cause of pancreatic cancer signs and symptoms, certain exams and tests will be conducted. The extent of cancer will be determined through further tests if cancer is detected. Medical history and physical exam: Your doctor needs to know your medical history to understand your symptoms. Smoking and your family history may also be asked about by your doctor. As part of your examination, your doctor will look for signs … Read more